The debug session cannot be established or it is unreliable.
Open Hardware | Debugger Hardware | Hardware Type and select your BlueBox.
Check if you are using the correct Debug Adapter for your target.
Check if the debugger is connected to the correct target debug connector. Multiple target connectors can have the same physical appearance and size but have different functionality.
Make sure that the pin 1 of the adapter is aligned with the pin 1 on the target.
Check if the target is turned on and if the power supply is applied to the microcontroller. Use a volt-meter for confirmation (particularly on targets without visual indication of power supply presence).
The target must be supplied with the voltage in the range that is defined for it. Check the target reference manual for power supply specifications.
Inspect the cable for any physical damage. If possible, check the connections with the ohm-meter. If it is damaged, contact Technical support for a replacement.